Genetic Structure of Susceptibility to Cardiovascular Continuum Comorbidity

We analyzed the genetic structure of susceptibility to comorbidity of cardiovascular disease continuum (CVDC) and assessed the functional significance of genetic variants associated with pathology. Association with CVDC was showed for SNPs that form the genetic structure of predisposition to CHD complicated by MI independent of the presence/absence of risk factors, such as rs1333049 (CDKN2B-AS1), rs3739998 (KIAA1462), rs3765124 (ADAMDEC1), and rs1007856 (ITGB5). The genetic variants rs626750 (MMP3/MMP12), rs1991401 (DDX5), rs2878771 (AQP2), and rs2277698 (TIMP2) are associated with CHD and MI depending on the presence of risk factors (AH, HC, and DM2). The genetic variants rs3739998 (KIAA1462), rs1991401 (DDX5), rs2878771 (AQP2) are associated with MI without comorbidities; rs1333049 (CDKN2B-AS1), rs3765124 (ADAMDEC1), rs1007856 (ITGB5) are associated with MI + AH; rs1333049 (CDKN2B-AS1), rs3765124 (ADAMDEC1), rs1007856 (ITGB5), rs626750 (MMP3/MMP12) are associated with IM + AG + HC; and rs3739998 (KIAA1462), rs2277698 (TIMP2) are associated with “CVDC syntropy”. All CVDC-associated SNPs are cis-eQTL and affect gene expressionin the tissues of CVDC target organs or change transcription factors affinity by the loss or appearance of their binding sites.

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