Interloci CNV Interactions in Variability of the Phenotypes of Neurodevelopmental Disorders

Most of pathogenetically significant copy number variations (CNV) are associated with neurodevelopmental phenotypes and characterized by incomplete penetrance and variable expressivity. However, the nature of these phenomena has not yet been disclosed. As a result, this leads to the uncertainty of prognosis in families with affected children having genetic variant associated with the disease, but inherited from apparently healthy parentsthat is a problemfor genetic counseling in medicine. This review discusses the evidence for the contribution of interloci interaction between different CNV to variability of clinical manifestations of neuropsychiatric and intellectual disorders

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