Genetic Diversity of North Eurasia Populations by Genetic Markers Associated with Diseases Impairing Human Cognitive Functions

The genetic diversity of sixteen native populations of North Eurasia is investigated using a panel of genetic markers in genes associated, according to the data of genome-wide association studies, with diseases that lead to impaired human cognitive functions (schizophrenia, Alzheimer’s disease, and their cognitive endophenotypes). There is a decrease in genetic diversity in the geographic space from west to east. The highest level of genetic diversity was shown in Caucasoid populations. There are two groups of SNPs that predominate in Caucasians or Mongoloids. The location of sixteen populations in the space of the principle components demonstrates their geographic localization. Clusterization of populations in accordance with their affiliation to four geographic regions was observed. In general, the analysis of within- and between-population genetic diversity for 28 markers in 16 populations replicates the patterns of the Northern Eurasia gene pool structure, which are described using other marker systems

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