The analysis of associations between cytokine network genes and inverse co-morbidity of bronchial asthma and tuberculosis

In the context of the studies of genetic causes of extremely rare co-existence of atopic bronchial asthma (BA) and tuberculosis (TB), an association study was carried out for the polymorphisms of IL1B, IL8, IL10, TNF, TNFRSF1B, and CXCL10 genes was carried out in 713 individuals from West Siberia. An association between the rs56061981 polymorphism of CXCL10 gene with TB was found. Also, an association of the rs1800872 variant of IL10 gene with both BA and pulmonary TB was identified. The results suggest the importance of IL10 gene in the development of BA and TB. Further studies of the IL10 signaling pathway will clarify the mechanisms by which the inverse co-morbidity between infectious and allergic diseases develops.

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