Role of microRNA in Development of Instability of Atherosclerotic Plaques

MicroRNAs are small non-coding single-strand RNAs that regulate gene expression. There are an increasing number of studies highlighting the important role of microRNAs in development and progression of cardiovascular diseases caused by atherosclerotic lesions of arteries. Here we review the available data on the association of microRNA expression with instability of atherosclerotic plaques in model animals and in humans. We emphasis data on miR-21, -100, -127, -133, -143/145, -221/222, and -494 because they were analyzed in more than one study. We discuss the possibility of using microRNAs in diagnosis and therapy of atherosclerosis and its complications.

Читать в источнике

ЭКО с ПГТ для семьи, отягощенной по болезни Гентингтона: клинический случай с успешным исходом

Differences in the Gene Pool Structure of Five Populations of Dagestan Revealed Using X-Chromosomal Microsatellite Markers

Различия в структуре генофонда пяти популяций населения Дагестана, выявленные с помощью X-хромосомных микросателлитных маркеров

Transcriptomics of severe COVID-19

Транскриптомика тяжелой формы COVID-19

МикроРНК miR-23b-3p и miR-27b-3p демонстрируют сильную обратную корреляцию экспрессии и метилирования ДНК в области промоторного региона гена MIR23B в атеросклеротических бляшках сонных артерий

First 2-year experience of nationwide newborn screening for severe forms of T and B cell immunode ﬁ ciency: 2.3 million newborns analyzed using TREC and KREC in Russia