Genetic factors predisposing to a chronic course of virus hepatitis and liver fibrosis

The IL4 C(−590)T, IL4RA Ile50Val, and TNF G(−308)A polymorphisms were tested for association with the chronic development of virus hepatitis, the extent of which was inferred from the liver fibrosis stage. The frequency of allele A of the TNF G(−208)A polymorphism in patients with mild fibrosis was higher (24.5%) than in patients with moderate or severe fibrosis (13.4%) or cirrhosis (8.7%). The frequency of heterozygous genotype CT of the IL4 C(−590)T polymorphism significantly differed between cirrhosis (68.2%) and moderate or severe fibrosis (39.1%).

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