Plasma antioxidant activity and chromosome aberrations in humans exposed to long-term low-dose γ-irradiation

Plasma antioxidant activity was evaluated in the lecithin-Fe2+ model system and cytogenetic studies were carried out in 16 men. A relationship between elevated antioxidant activity of the plasma and increased level of chromatid aberrations and with percentage of aberrant cells was detected in the experimental group, but no correlation was found between antioxidant activity and the integral dose of γ-irradiation and rate of its accumulation. An assumption was made about exhaustion of the “buffer capacity” of the antioxidant defense system resulting from long-term exposure to unidentified factors of technogenic nature increasing plasma antioxidant activity and level of chromosome aberrations. In subjects with high level of antioxidant defense, naturally low antioxidant activity and low percentage of chromatid aberrations were probably maintained.

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