Polymorphism of Noncoding Regions of the Mitochondrial Genome in the Indigenous Population of Southeastern Tuva Republic

Deletion-insertion polymorphism of the V region and restriction polymorphism of D-loop for seven restriction enzymes - AspS91 (Cfr13I isoschizomere), BamHI, Bme18I (AvaII), EcoRV, HaeIII, KpnI, and Kzo91 (Sau3AI) - in mitochondrial DNA (mt DNA) were studied in the indigenous population of southeastern Tuva Republic (N = 159). The results were compared with the data on Russians, Mongols, Buryats, and Altaians. Tuvinians significantly differed from Mongols in the frequency of the 9-bp deletion of the V region (1.89 and 8.07%, respectively). Additionally, significant differences between Tuvinians and samples of Mongols and Russians were obtained for frequencies of the AspS9I, HaeIII, and KpnI restriction sites. A comparison of the polymorphism of the mitochondrial genome in individuals of different sexes and ages was performed in the studied sample.Читать в источнике